Thiadiazine Derivatives as Antiprotozoal New Drugs

Bermello, Julieta Coro; Piñeiro, Rolando Pérez; Fidalgo, Lianet Monzote; Cabrera, Hortensia Rodríguez; Navarro, Margarita Suárez

Thiadiazine Derivatives as Antiprotozoal New Drugs

Julieta Coro Bermello^a, Rolando Pérez Piñeiro^b, Lianet Monzote Fidalgo^c, Hortensia Rodríguez Cabrera^{*, a}, Margarita Suárez Navarro^a

^a Laboratorio de Síntesis Orgánica. Facultad de Quimica, Universidad de La Habana 10400-Ciudad Habana, Cuba;

^b National Institute of Nanotechnology, National Research Council (NINT-NRC), and Department of Chemistry, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada;

^c Departamento de Parasitología, Instituto de Medicina Tropical “Pedro Kourí”, Ciudad Habana, Cuba

Article Information

Identifiers and Pagination:

Year: 2011
Volume: 5
First Page: 51
Last Page: 60
Publisher ID: TOMCJ-5-51
DOI: 10.2174/1874104501105010051

Article History:

Received Date: 2/2/2010
Revision Received Date: 29/4/2010
Acceptance Date: 15/6/2010
Electronic publication date: 9/3/2011
Collection year: 2011

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© Bermello et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this autor at the Laboratorio de Síntesis Orgánica. Facultad de Quimica, Universidad de La Habana 10400-Ciudad Habana, Cuba; Tel 878-1398; E-mails: horten@fq.uh.cu; hortensia_cu@yahoo.es

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.

Keywords: Tetrahydro-2H-1,3,5-thiadiazine-2-thione, antiprotozoan activity.

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RESEARCH ARTICLE

Thiadiazine Derivatives as Antiprotozoal New Drugs

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