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Controlled cell patterning on bioactive surfaces with special wettability

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Abstract

The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the ability to control the cell-surface interaction is complicated by the complexity in the physiochemical features of bioactive surfaces. In particular, the manifestation of special wettability rendered by the combination of surface roughness and surface chemistry further enriches the cell-surface interaction. Herein we investigated the cell adhesion behaviors of Circulating Tumor Cells (CTCs) on topographically patterned but chemically homogeneous surfaces. Harnessing the distinctive cell adhesion on surfaces with different topography, we further explored the feasibility of controlled cell patterning using periodic lattices of alternative topographies. We envision that our method provides a designer’s toolbox to manage the extracellular environment.

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Authors and Affiliations

  1. Science and Technology on Microsystem Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China

    Xiaofeng Zhou & Lufeng Che

  2. Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China

    Jiaqian Li & Zuankai Wang

  3. Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, 999077, China

    Hongyan Sun

  4. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China

    Yi Hu

  5. College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, 310027, China

    Lufeng Che

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  1. Xiaofeng Zhou
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  2. Jiaqian Li
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  4. Yi Hu
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  5. Lufeng Che
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Correspondence to Lufeng Che or Zuankai Wang.

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Zhou, X., Li, J., Sun, H. et al. Controlled cell patterning on bioactive surfaces with special wettability. J Bionic Eng 14, 440–447 (2017). https://doi.org/10.1016/S1672-6529(16)60409-2

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  • DOI: https://doi.org/10.1016/S1672-6529(16)60409-2

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