Abstract
A direct solid-phase synthesis of a series of substituted benzimidazole-containing peptides is described. The method involves on-resin formation of new amino acids containing benzimidazole derivatives in the side chain. The heterocycle conjugates were obtained by reaction between aldehydes and peptides containing β-(3,4-diaminophenyl)alanine residue, immobilized on a polymeric solid support.
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Acknowledgments
This work was supported in part by grants No. 3 T09A 029 28 and N N204 249934 from the State Committee for Scientific Research (Poland). We thank Dr. Anna Staszewska for technical assistance.
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Koprowska-Ratajska, M., Kluczyk, A., Stefanowicz, P. et al. Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines. Amino Acids 36, 309–315 (2009). https://doi.org/10.1007/s00726-008-0070-5
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DOI: https://doi.org/10.1007/s00726-008-0070-5